Glomerular proteinuria is a hallmark of kidney disease, and is a risk factor for progression to renal failure. Since the onset of nephrotic syndrome is similar in adults and children, this proposal will focus on the identification of novel targets and therapeutic strategies for therapy of a nephrotic syndrome as well as for the development of novel biomarkers for prognosis of patients with nephrotic syndrome. Clinical studies have demonstrated that a number of non-nephrotic causes of 2336c5e09f
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